{"id":79164,"date":"2024-10-17T18:31:45","date_gmt":"2024-10-17T18:31:45","guid":{"rendered":"https:\/\/pdfstandards.shop\/product\/uncategorized\/asme-bpe-2012\/"},"modified":"2024-10-24T19:39:16","modified_gmt":"2024-10-24T19:39:16","slug":"asme-bpe-2012","status":"publish","type":"product","link":"https:\/\/pdfstandards.shop\/product\/publishers\/asme\/asme-bpe-2012\/","title":{"rendered":"ASME BPE 2012"},"content":{"rendered":"

This ASME Standard provides the requirements applicable to the design of equipment used in the bioprocessing, pharmaceutical and personal-care products industries, as well as other applications with relatively high levels of hygienic requirements. It covers materials, design, fabrication, inspections, testing and certification. ASME-BPE is unique in the world, having resulted from widespread industry requests for standardization. It is the leading Standard on how to design and build equipment and systems used in the production of biopharmaceuticals. It incorporates current best-practices for enhancing product purity and safety. Companies that rigorously apply ASME-BPE often can achieve production efficiencies, lower development and manufacturing costs, and increase quality and safety, while complying with regulations. New topics from the last revision include: Transfer panel and jumper tolerances Documentation requirements Hygienic support systems\/rotary lobe pumps\/static & dynamic spray devices\/sampling systems\/filtration & chromatography systems design Weld discoloration acceptance criteria Dynamic seal performance Properties of polymeric materials Process instrumentation ASME-BPE is referenced in ASME<\/p>\n

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PDF Pages<\/th>\nPDF Title<\/th>\n<\/tr>\n
3<\/td>\nErrata to ASME BPE-2012 <\/td>\n<\/tr>\n
13<\/td>\nCONTENTS <\/td>\n<\/tr>\n
19<\/td>\nFOREWORD <\/td>\n<\/tr>\n
20<\/td>\nSTATEMENT OF POLICY ON THE USE OF CERTIFICATION MARKS AND CODE AUTHORIZATION IN ADVERTISING
STATEMENT OF POLICY ON THE USE OF ASME MARKING TO IDENTIFY MANUFACTURED ITEMS <\/td>\n<\/tr>\n
21<\/td>\nCOMMITTEE ROSTER <\/td>\n<\/tr>\n
25<\/td>\nSUMMARY OF CHANGES <\/td>\n<\/tr>\n
29<\/td>\nPart GR General Requirements
GR- 1 INTRODUCTION
GR- 2 SCOPE OF THE ASME BPE STANDARD
GR- 3 MANUFACTURER’S QUALITY ASSURANCE PROGRAM <\/td>\n<\/tr>\n
30<\/td>\nGR- 4 INSPECTION
GR- 4.1 Inspector\/ Examiner
GR- 4.2 Inspector’s Delegate <\/td>\n<\/tr>\n
31<\/td>\nTables
Table GR- 4.2- 1 Inspector’s Delegate Capabilities <\/td>\n<\/tr>\n
32<\/td>\nTable GR- 4.2- 1 Inspector’s Delegate Capabilities ( Cont’d) <\/td>\n<\/tr>\n
33<\/td>\nGR- 4.3 Responsibilities
GR- 4.4 Access for Inspectors
GR- 5 DOCUMENTATION REQUIREMENTS
GR- 5.1 Part SD <\/td>\n<\/tr>\n
34<\/td>\nGR- 5.2 Part DT
GR- 5.3 Part MJ <\/td>\n<\/tr>\n
35<\/td>\nGR- 5.4 Part SF
GR- 5.5 Part PM <\/td>\n<\/tr>\n
36<\/td>\nGR- 5.6 Part SG
GR- 6 METRIC
GR- 7 REFERENCES <\/td>\n<\/tr>\n
38<\/td>\nGR- 8 TERMS AND DEFINITIONS <\/td>\n<\/tr>\n
45<\/td>\nPart SD Systems Design
SD- 1 PURPOSE AND SCOPE
SD- 2 GENERAL GUIDELINES
SD- 2.1 Containment
SD- 2.2 Bioburden Control
SD- 2.3 Bioburden Reduction
SD- 2.4 Fabrication <\/td>\n<\/tr>\n
47<\/td>\nTable SD- 2.4.3.1- 1 Slope Designations for Gravity- Drained Lines <\/td>\n<\/tr>\n
48<\/td>\nSD- 3 PROCESS COMPONENTS
SD- 3.1 Connections, Fittings, and Piping <\/td>\n<\/tr>\n
49<\/td>\nFigures
\n
Fig. SD- 3.1.1- 1 Flat Gasket Applications <\/td>\n<\/tr>\n
50<\/td>\nDimensions for Flow- Through Tee: Full- Size Standard Straight Tee With Blind Cap
Table SD- 3.1.2.2- 1 <\/td>\n<\/tr>\n
51<\/td>\nDimensions for Flow- Through Tee: Short Outlet Reducing Tee With Blind Cap
Table SD- 3.1.2.2- 2 <\/td>\n<\/tr>\n
52<\/td>\nDimensions for Flow- Through Tee: Short Outlet Reducing Tee With Blind Cap ( Cont’d)
Table SD- 3.1.2.2- 2 <\/td>\n<\/tr>\n
53<\/td>\nFig. SD- 3.1.2.2- 1 Accepted Point- of- Use Designs <\/td>\n<\/tr>\n
54<\/td>\nFig. SD- 3.1.2.3- 1 Double Block- and- Bleed Valve Assembly <\/td>\n<\/tr>\n
55<\/td>\nSD- 3.2 Hose Assemblies
SD- 3.3 Pumps <\/td>\n<\/tr>\n
56<\/td>\nFig. SD- 3.2.1- 1 Flexible Hygienic Hose Design <\/td>\n<\/tr>\n
57<\/td>\nFig. SD- 3.3.2.2- 1 Pump Impeller Configurations
Fig. SD- 3.3.2.2- 2 Acceptable Impeller Attachments <\/td>\n<\/tr>\n
58<\/td>\nRatios
Fig. SD- 3.3.2.2- 3 Casing Drain Configurations
Fig. SD- 3.3.2.2- 4 Casing Drain <\/td>\n<\/tr>\n
59<\/td>\nSD- 3.4 Vessels
Fig. SD- 3.3.2.4- 1 Rotary Lobe Pump Rotor Attachment <\/td>\n<\/tr>\n
60<\/td>\nFig. SD- 3.4.2- 1 Nozzle Design <\/td>\n<\/tr>\n
61<\/td>\nFig. SD- 3.4.2- 2 Side and Bottom Connections
Fig. SD- 3.4.2- 3 Sidewall Instrument Ports <\/td>\n<\/tr>\n
62<\/td>\nFig. SD- 3.4.2- 4 Accepted Nozzle Penetrations
Table SD- 3.4.2- 1 Annular Spacing Recommendations for Hygienic Dip Tubes <\/td>\n<\/tr>\n
63<\/td>\nFig. SD- 3.4.2- 5 Vessel Design Tangential Nozzles <\/td>\n<\/tr>\n
64<\/td>\nFig. SD- 3.4.2- 6 Sight Glass Design ( Accepted) <\/td>\n<\/tr>\n
65<\/td>\nSD- 3.5 Agitators and Mixers
Fig. SD- 3.4.2- 7 Typical Nozzle Detail <\/td>\n<\/tr>\n
66<\/td>\nFig. SD- 3.4.3- 1 Internal Support Members <\/td>\n<\/tr>\n
68<\/td>\nFig. SD- 3.5.1- 1 Agitator Mounting Flanges <\/td>\n<\/tr>\n
69<\/td>\nFig. SD- 3.5.2- 1 Shaft Coupling Construction
Fig. SD- 3.5.2- 2 Shaft Coupling Seal Arrangements <\/td>\n<\/tr>\n
70<\/td>\nFig. SD- 3.5.2- 3 Fastener Seal Arrangements <\/td>\n<\/tr>\n
71<\/td>\nFig. SD- 3.5.5- 1 Shaft Steady Bearing <\/td>\n<\/tr>\n
72<\/td>\nSD- 3.6 Heat Exchange Equipment
Fig. SD- 3.5.5- 2 Magnetically Coupled Mixer ( Typical Bottom- Mount) <\/td>\n<\/tr>\n
73<\/td>\nSD- 3.7 Transfer Panels <\/td>\n<\/tr>\n
74<\/td>\nFig. SD- 3.6.1- 1 Double Tubesheet Heat Exchanger Bonnet Design <\/td>\n<\/tr>\n
75<\/td>\nFig. SD- 3.7.1- 1 Transfer Panel Looped Headers <\/td>\n<\/tr>\n
76<\/td>\nFig. SD- 3.7.2- 1 Transfer Panel Tolerances ( Reference Table DT- 7- 2) <\/td>\n<\/tr>\n
77<\/td>\nSD- 3.8 Filters
SD- 3.9 Spray Devices <\/td>\n<\/tr>\n
78<\/td>\nFig. SD- 3.7.4- 1 Transfer Panel Jumpers <\/td>\n<\/tr>\n
79<\/td>\nFig. SD- 3.9.1- 1 Dynamic Spray Device: Single Axis ( Spray Pattern for Illustration Purposes) Fig. SD- 3.9.1- 2 Two Axes Dynamic Spray Device ( Number of Jets Are for Illustration Purposes) <\/td>\n<\/tr>\n
81<\/td>\nFig. SD- 3.9.2.1- 1 Static Spray Device
Fig. SD- 3.9.2.1- 2 Flow Rate Guideline for Vertical Cylindrical Vessels <\/td>\n<\/tr>\n
82<\/td>\nFig. SD- 3.9.2.1- 3 Flow Rate Guideline for Horizontal Cylindrical Vessels
Fig. SD- 3.9.2.3- 1 Impact Pattern Build- Up <\/td>\n<\/tr>\n
83<\/td>\nSD- 3.10 Disposables That Require Pre- Sterilization or Post- Sterilization
SD- 3.11 Sampling Systems
SD- 3.12 Steam Traps
SD- 3.13 Check Valves
SD- 3.14 Orifice Plates
SD- 3.15 Relief Devices <\/td>\n<\/tr>\n
84<\/td>\nFig. SD- 3.12- 1 Steam Traps for Clean Steam Systems
SD- 3.16 Liquid Pressure Regulators
SD- 4 PROCESS UTILITIES
SD- 4.1 Compendial Water Systems <\/td>\n<\/tr>\n
85<\/td>\nFig. SD- 4.1.2.1- 1 Point- of- Use Piping <\/td>\n<\/tr>\n
86<\/td>\nFig. SD- 4.1.2.2- 1 Physical Break in Point- of- Use Piping
SD- 4.2 Clean\/ Pure Steam Systems <\/td>\n<\/tr>\n
87<\/td>\nFig. SD- 4.2.2- 1 Typical Clean Steam System Isometric <\/td>\n<\/tr>\n
88<\/td>\nFig. SD- 4.2.2- 2 Clean Steam Point- of- Use Design
SD- 4.3 Process Gases <\/td>\n<\/tr>\n
89<\/td>\nSD- 4.4 Process Waste Systems
SD- 5 PROCESS SYSTEMS
SD- 5.1 Upstream Systems <\/td>\n<\/tr>\n
90<\/td>\nFig. SD- 5.1.1.1- 1 Fermentor Sterile Envelope <\/td>\n<\/tr>\n
91<\/td>\nFig. SD- 5.1.1.1- 2 Bioreactor Sterile Envelope <\/td>\n<\/tr>\n
93<\/td>\nFig. SD- 5.1.1.2.3- 1 Gas Sparging Assembly \u2014 Lance <\/td>\n<\/tr>\n
94<\/td>\nFig. SD- 5.1.1.2.3- 2 Gas Sparging Assembly \u2014 Sintered <\/td>\n<\/tr>\n
95<\/td>\nFig. SD- 5.1.1.2.3- 3 Gas Sparging Assembly \u2014 Ring <\/td>\n<\/tr>\n
96<\/td>\nFig. SD- 5.1.1.2.3- 4 Gas Sparging Assembly \u2014 Single Orifice <\/td>\n<\/tr>\n
97<\/td>\nFig. SD- 5.1.1.3.1- 1 Exhaust Gas Condenser
Fig. SD- 5.1.1.3.1- 2 Exhaust Gas Heater <\/td>\n<\/tr>\n
98<\/td>\nFig. SD- 5.1.1.3.1- 3 Electrically Heat Traced Filter Housing <\/td>\n<\/tr>\n
100<\/td>\nFig. SD- 5.2.1- 1 Tank\/ Vessel Vent Filters
SD- 5.2 Downstream Systems <\/td>\n<\/tr>\n
101<\/td>\nSD- 5.3 Process Support Systems <\/td>\n<\/tr>\n
104<\/td>\nTable SD- 5.3.3.3- 1 Flow Rates to Achieve 5 ft\/ sec ( 1.52 m\/ s) <\/td>\n<\/tr>\n
105<\/td>\nFig. SD- 5.3.3.5.1- 1 CIP Looped Header ( Supply or Return) <\/td>\n<\/tr>\n
106<\/td>\nFig. SD- 5.3.3.5.1- 2 Zero- Static Chain
Fig. SD- 5.3.3.5.1- 3 Swing Elbow Arrangement <\/td>\n<\/tr>\n
107<\/td>\nSD- 6 TESTING
SD- 6.1 Spray Device Coverage Test
SD- 6.2 Cleaning, Steaming, and Bioburden Control Testing
SD- 6.3 Hydrostatic Test
SD- 6.4 Vessel Drainability Test <\/td>\n<\/tr>\n
109<\/td>\nPart DT Dimensions and Tolerances for Process Components
DT- 1 PURPOSE AND SCOPE
DT- 2 PRESSURE RATING
DT- 3 WALL THICKNESS
DT- 4 DIMENSIONS
DT- 4.1 Fitting Dimensions
DT- 4.2 Nonstandard Fitting Dimensions
DT- 4.3 Special Angle Fittings Dimensions
DT- 4.4 Valve Dimensions <\/td>\n<\/tr>\n
110<\/td>\nDT- 5 MATERIALS
DT- 6 TESTS
DT- 7 TOLERANCES
DT- 8 WELD ENDS
DT- 9 HYGIENIC CLAMP UNIONS
DT- 9.1 Typical Hygienic Clamp Unions
DT- 9.2 Hygienic Gaskets
DT- 9.3 Connections
DT- 9.4 Hygienic Clamps
DT- 10 MINIMUM EXAMINATION REQUIREMENTS
DT- 10.1 Visual Inspection <\/td>\n<\/tr>\n
111<\/td>\nDT- 10.2 Documentation Verification
DT- 10.3 Physical Examination
DT- 11 MARKING
DT- 11.1 Fitting Marking Information
DT- 11.2 Valve Marking Information
DT- 12 PACKAGING <\/td>\n<\/tr>\n
112<\/td>\nTable DT- 2- 1 Hygienic Unions: Rated Internal Working Pressure <\/td>\n<\/tr>\n
113<\/td>\nFig. DT- 2- 1 Clamp Conditions at Installation <\/td>\n<\/tr>\n
114<\/td>\nTable DT- 3- 1 Final Tolerances for Mechanically Polished Fittings and Process Components <\/td>\n<\/tr>\n
115<\/td>\nTable DT- 3- 2 Final Tolerances for Electropolished Fittings and Process Components
Table DT- 4- 1 Nominal O. D. Tubing Sizes
Table DT- 4.1- 1 Tangent Lengths <\/td>\n<\/tr>\n
116<\/td>\nTable DT- 4.1.1- 1 Automatic Tube Weld: 90- deg Elbow
Table DT- 4.1.1- 2 Automatic Tube Weld: Hygienic Clamp Joint, 90- deg Elbow <\/td>\n<\/tr>\n
117<\/td>\nTable DT- 4.1.1- 3 Hygienic Clamp Joint: 90- deg Elbow
Table DT- 4.1.1- 4 Automatic Tube Weld: 45- deg Elbow <\/td>\n<\/tr>\n
118<\/td>\nTable DT- 4.1.1- 5 Automatic Tube Weld: Hygienic Clamp Joint, 45- deg Elbow
Table DT- 4.1.1- 6 Hygienic Clamp Joint: 45- deg Elbow <\/td>\n<\/tr>\n
119<\/td>\nTable DT- 4.1.1- 7 Automatic Tube Weld: 180- deg Return Bend
Table DT- 4.1.1- 8 Hygienic Clamp Joint: 180- deg Return Bend <\/td>\n<\/tr>\n
120<\/td>\nTable DT- 4.1.2- 1 Automatic Tube Weld: Straight Tee and Cross
Table DT- 4.1.2- 2 Automatic Tube Weld: Short Outlet Hygienic Clamp Joint Tee <\/td>\n<\/tr>\n
121<\/td>\nTable DT- 4.1.2- 3 Hygienic Mechanical Joint: Short Outlet Run Tee
Table DT- 4.1.2- 4 Hygienic Clamp Joint: Straight Tee and Cross <\/td>\n<\/tr>\n
122<\/td>\nTable DT- 4.1.2- 5 Hygienic Clamp Joint: Short Outlet Tee
Table DT- 4.1.2- 6 Automatic Tube Weld: Reducing Tee <\/td>\n<\/tr>\n
123<\/td>\nTable DT- 4.1.2- 7 Automatic Tube Weld: Short Outlet Hygienic Clamp, Joint Reducing Tee <\/td>\n<\/tr>\n
124<\/td>\nTable DT- 4.1.2- 8 Hygienic Clamp Joint: Reducing Tee <\/td>\n<\/tr>\n
125<\/td>\nTable DT- 4.1.2- 9 Hygienic Clamp Joint: Short Outlet Reducing Tee
Table DT- 4.1.2- 10 Automatic Tube Weld: Instrument Tee
Table DT- 4.1.2- 11 Hygienic Clamp Joint: Instrument Tee <\/td>\n<\/tr>\n
126<\/td>\nTable DT- 4.1.3- 1( a) Automatic Tube Weld: Concentric and Eccentric Reducer <\/td>\n<\/tr>\n
127<\/td>\nTable DT- 4.1.3- 1( b) Automatic Tube Weld: Concentric and Eccentric Reducer <\/td>\n<\/tr>\n
128<\/td>\nTable DT- 4.1.3- 2( a) Hygienic Clamp Joint: Tube Weld Concentric and Eccentric Reducer <\/td>\n<\/tr>\n
129<\/td>\nTable DT- 4.1.3- 2( b) Hygienic Clamp Joint: Tube Weld Concentric and Eccentric Reducer <\/td>\n<\/tr>\n
130<\/td>\nTable DT- 4.1.3- 3( a) Hygienic Clamp Joint: Concentric and Eccentric Reducer <\/td>\n<\/tr>\n
131<\/td>\nTable DT- 4.1.3- 3( b) Hygienic Clamp Joint: Concentric and Eccentric Reducer <\/td>\n<\/tr>\n
132<\/td>\nTable DT- 4.1.4- 1 Automatic Tube Weld: Ferrule <\/td>\n<\/tr>\n
133<\/td>\nTable DT- 4.1.5- 1 Automatic Tube Weld: Cap
Table DT- 4.1.5- 2 Hygienic Clamp Joint: Solid End Cap
Table DT- 4.4.1- 1 Hygienic Clamp Joint: Weir Style Diaphragm Valve <\/td>\n<\/tr>\n
134<\/td>\nTable DT- 7- 1 Hygienic Clamp Ferrule Standard Dimensions and Tolerances <\/td>\n<\/tr>\n
135<\/td>\nTable DT- 7- 1 Hygienic Clamp Ferrule Standard Dimensions and Tolerances ( Cont’d) <\/td>\n<\/tr>\n
136<\/td>\nTable DT- 7- 2 Transfer Panel and Jumper Tolerances <\/td>\n<\/tr>\n
137<\/td>\nTable DT- 9.3- 1 Hygienic Clamp Ferrule: Design Criteria <\/td>\n<\/tr>\n
138<\/td>\nPart MJ Material Joining
MJ- 1 PURPOSE AND SCOPE
MJ- 2 MATERIALS
MJ- 2.1 Base Metals
MJ- 2.2 Filler Metals
MJ- 2.3 Nonmetallics
MJ- 3 WELD JOINT DESIGN AND PREPARATION
MJ- 3.1 General <\/td>\n<\/tr>\n
139<\/td>\nMJ- 3.2 Pressure Vessels and Tanks
MJ- 3.3 Piping
MJ- 3.4 Tubing
MJ- 3.5 Tube- Attachment Welds
MJ- 4 JOINING PROCESSES AND PROCEDURES
MJ- 4.1 Welds Finished After Welding
MJ- 4.2 Welds Used in the As- Welded Condition <\/td>\n<\/tr>\n
140<\/td>\nMJ- 5 PROCEDURE QUALIFICATIONS
MJ- 5.1 Pressure Vessels and Tanks
MJ- 5.2 Piping
MJ- 5.3 Tubing
MJ- 5.4 Duplex Stainless Steels
MJ- 6 PERFORMANCE QUALIFICATIONS
MJ- 6.1 Pressure Vessels and Tanks
MJ- 6.2 Piping
MJ- 6.3 Tubing
MJ- 7 EXAMINATION, INSPECTION, AND TESTING
Table MJ- 6.2- 1 Tube\/ Pipe Diameter Limits for Orbital GTAW Performance Qualification
Table MJ- 6.2- 2 Weld Thickness Limits for Orbital GTAW Performance Qualification <\/td>\n<\/tr>\n
141<\/td>\nMJ- 7.1 Examination Procedures
MJ- 7.2 Personnel Requirements
MJ- 7.3 Examination, Inspection, and Testing Requirements <\/td>\n<\/tr>\n
142<\/td>\nMJ- 7.4 Records
MJ- 8 WELD ACCEPTANCE CRITERIA
MJ- 8.1 General
MJ- 8.2 Pressure Vessels and Tanks
MJ- 8.3 Piping
MJ- 8.4 Tubing
MJ- 8.5 Tube- Attachment Welds
MJ- 9 DOCUMENTATION REQUIREMENTS
MJ- 10 PASSIVATION <\/td>\n<\/tr>\n
143<\/td>\nTable MJ- 8.2- 1 Acceptance Criteria for Welds on Pressure Vessels and Tanks <\/td>\n<\/tr>\n
144<\/td>\nTable MJ- 8.3- 1 Acceptance Criteria for Welds on Pipe <\/td>\n<\/tr>\n
145<\/td>\nTable MJ- 8.4- 1 Acceptance Criteria for Groove Welds on Tube- to- Tube Butt Joints <\/td>\n<\/tr>\n
146<\/td>\nTable MJ- 8.4- 1 Acceptance Criteria for Groove Welds on Tube- to- Tube Butt Joints ( Cont’d) <\/td>\n<\/tr>\n
147<\/td>\nFig. MJ- 8.4- 1 Acceptable and Unacceptable Weld Profiles for Tube Welds <\/td>\n<\/tr>\n
148<\/td>\nFig. MJ- 8.4- 2 Discoloration Acceptance Criteria for Weld Heat- Affected Zones on Electropolished 316L Tubing <\/td>\n<\/tr>\n
149<\/td>\nFig. MJ- 8.4- 3 Discoloration Acceptance Criteria for Weld Heat- Affected Zones on Mechanically Polished 316L Tubing <\/td>\n<\/tr>\n
150<\/td>\nTable MJ- 8.5- 1 Acceptance Criteria for Tube- Attachment Welds [ See Note ( 1)] <\/td>\n<\/tr>\n
151<\/td>\nPart SF Product Contact Surface Finishes
SF- 1 PURPOSE AND SCOPE
SF- 2 METALLIC APPLICATIONS
SF- 2.1 Applicable Systems
SF- 2.2 Acceptance Criteria
SF- 2.3 Inspection and Techniques Employed in the Classification of Product Contact Surface Finishes
SF- 2.4 Surface Condition
SF- 2.5 Electropolishing Procedure Qualification
SF- 2.6 Passivation Procedure <\/td>\n<\/tr>\n
152<\/td>\nTable SF- 2.2- 1 Acceptance Criteria for Metallic Product Contact Surface Finishes <\/td>\n<\/tr>\n
153<\/td>\nSF- 2.7 Normative References
Table SF- 2.2- 2 Additional Acceptance Criteria for Electropolished Metallic Product Contact Surface Finishes
Table SF- 2.4- 1 <\/td>\n<\/tr>\n
154<\/td>\nSF- 2.8 Rouge and Stainless Steel
SF- 3 POLYMERIC APPLICATIONS
SF- 3.1 Applicable Systems
SF- 3.2 Materials
SF- 3.3 Inspection and Techniques Employed in the Classification of Product Contact Surface Finishes
Table SF- 2.6- 1 Acceptance Criteria for Metallic Passivated Product Contact Surface Finishes <\/td>\n<\/tr>\n
155<\/td>\nReadings for Polymeric Product Contact Surfaces
SF- 3.4 Surface Condition
Table SF- 3.3- 1 Acceptance Criteria for Polymeric Product Contact Surface Finishes
Table SF- 3.4- 1 <\/td>\n<\/tr>\n
156<\/td>\nPart SG Sealing Components
SG- 1 PURPOSE AND SCOPE
SG- 2 SEALING COMPONENT TYPES
SG- 2.1 General
SG- 2.2 Static Seals
SG- 2.3 Dynamic Seals <\/td>\n<\/tr>\n
157<\/td>\nFig. SG- 2.2.2- 1 Hygienic Union per Table DT- 7- 1
Fig. SG- 2.2.2- 2 Hygienic Clamp Union per Table DT- 7- 1 <\/td>\n<\/tr>\n
158<\/td>\nFig. SG- 2.2.2- 3 Hygienic Union per DIN 11864
Fig. SG- 2.2.2- 4 Hygienic Clamp Union per DIN 11864 <\/td>\n<\/tr>\n
159<\/td>\nFig. SG- 2.2.2- 5 Nonhygienic Connections <\/td>\n<\/tr>\n
160<\/td>\nFig. SG- 2.3.1.2- 1 Weir Valves <\/td>\n<\/tr>\n
161<\/td>\nFig. SG- 2.3.1.2- 2 Radial Valves
Fig. SG- 2.3.1.2- 3 Weirless Diaphragm Valve <\/td>\n<\/tr>\n
162<\/td>\nFig. SG- 2.3.1.2- 4 Linear Control Valves
Fig. SG- 2.3.1.2- 5 Regulator Valve <\/td>\n<\/tr>\n
163<\/td>\nFig. SG- 2.3.1.3- 1 Ball Valves
Fig. SG- 2.3.1.4- 1 Rising Stem Single Valve, Double Seat Mix Proof Valve, and Needle Valve <\/td>\n<\/tr>\n
164<\/td>\nFig. SG- 2.3.1.5- 1 Butterfly Valve Fig. SG- 2.3.1.7- 1 Back Pressure Control Valve <\/td>\n<\/tr>\n
165<\/td>\nFig. SG- 2.3.1.8- 1 Pinch Valve
Fig. SG- 2.3.1.9- 1 Pressure Relief and Check Valves
Fig. SG- 2.3.1.10- 1 Plug Valve <\/td>\n<\/tr>\n
166<\/td>\nFig. SG- 2.3.2.2- 1 Single Mechanical Seal
Fig. SG- 2.3.2.2- 2 Single Seal for Top Entry Agitator <\/td>\n<\/tr>\n
167<\/td>\nFig. SG- 2.3.2.3- 1 Dual Pressurized Mechanical Seal for Pumps
Fig. SG- 2.3.2.3- 2 Dual Pressurized Mechanical Seal for Top Entry Agitator
Fig. SG- 2.3.2.3- 3 Dual Unpressurized Mechanical Seal for Pumps <\/td>\n<\/tr>\n
168<\/td>\nFig. SG- 2.3.2.4- 1 Flush Plan 01
Fig. SG- 2.3.2.4- 2 Flush Plan 02
Fig. SG- 2.3.2.4- 3 Flush Plan 11 <\/td>\n<\/tr>\n
169<\/td>\nFig. SG- 2.3.2.4- 4 Flush Plan 32
Fig. SG- 2.3.2.4- 5 Flush Plan 52 for Pump <\/td>\n<\/tr>\n
170<\/td>\nFig. SG- 2.3.2.4- 6 Flush Plan 52 for Top Entry Agitator
Fig. SG- 2.3.2.4- 7 Flush Plan BPE52 for Pump
Fig. SG- 2.3.2.4- 8 Flush Plan 53 for Pump
Fig. SG- 2.3.2.4- 9 Flush Plan 53 for Top Entry Agitator <\/td>\n<\/tr>\n
171<\/td>\nFig. SG- 2.3.2.4- 10 Flush Plan 54 for Pump
Fig. SG- 2.3.2.4- 11 Flush Plan 54 for Top Entry Agitator
Fig. SG- 2.3.2.4- 12 Flush Plan 74 for Pump
Fig. SG- 2.3.2.4- 13 Flush Plan 74 for Top Entry Agitator <\/td>\n<\/tr>\n
172<\/td>\nSG- 3 SEALING COMPONENTS GENERAL DESIGN REQUIREMENTS ( GENERAL PROVISIONS)
SG- 3.1 Seal Design Conditions
SG- 3.2 System Requirements
SG- 3.3 Seal Construction <\/td>\n<\/tr>\n
174<\/td>\nFig. SG- 3.3.2.2- 1 Static O- Ring <\/td>\n<\/tr>\n
176<\/td>\nFig. SG- 3.3.2.3- 1 Seals for Rising Stem Valves <\/td>\n<\/tr>\n
177<\/td>\nSG- 3.4 Compliance Requirements for Sealing Elements <\/td>\n<\/tr>\n
178<\/td>\nSG- 3.5 Seal Identification
SG- 3.6 Other Seal Requirements
SG- 4 SEAL PERFORMANCE REQUIREMENTS
SG- 4.1 General Requirements
SG- 4.2 Static Seal Performance <\/td>\n<\/tr>\n
179<\/td>\nSG- 4.3 Dynamic Seal Performance
Fig. SG- 4.2- 1 Typical Hygienic Clamp Union: Allowable Gasket Intrusion <\/td>\n<\/tr>\n
180<\/td>\nSG- 5 SEAL APPLICATIONS
SG- 5.1 General Considerations
SG- 5.2 Process Systems
SG- 5.3 Compendial Water Systems
SG- 5.4 Clean\/ USP Pure Steam
SG- 5.5 CIP <\/td>\n<\/tr>\n
181<\/td>\nPart PM Polymeric and Other Nonmetallic Materials
PM- 1 PURPOSE AND SCOPE
PM- 2 MATERIALS
PM- 2.1 Materials of Construction <\/td>\n<\/tr>\n
182<\/td>\nPM- 2.2 General Requirements
Table PM- 2.1.1- 1 Common Thermoplastic Polymers and Applications
Table PM- 2.1.2- 1 Common Thermoset Polymers and Applications <\/td>\n<\/tr>\n
183<\/td>\nPM- 3 PROPERTIES AND PERFORMANCE
PM- 3.1 Biocompatibility
Table PM- 2.1.3- 1 Examples of Nonmetallics <\/td>\n<\/tr>\n
184<\/td>\nPM- 3.2 Extractables and Leachables
Table PM- 2.2.1- 1 Information of Certificate of Compliance <\/td>\n<\/tr>\n
185<\/td>\nPM- 3.3 Physical and Mechanical Properties of Thermoplastic Polymers
PM- 3.4 Chemical Compatibility of Thermoplastic Polymers
PM- 3.5 Physical and Mechanical Properties of Thermoset Polymers
PM- 3.6 Chemical Compatibility of Thermoset Elastomers
PM- 3.7 Polymeric Surface Finish
PM- 4 APPLICATIONS
PM- 4.1 Single- Use Components and Assemblies <\/td>\n<\/tr>\n
187<\/td>\nPM- 4.2 Piping <\/td>\n<\/tr>\n
188<\/td>\nTable PM- 4.2.1- 1 Size Comparison of Common Thermoplastic Sizing Standards <\/td>\n<\/tr>\n
191<\/td>\nPM- 4.3 Hose Assemblies
Fig. PM- 4.2.8.1- 1 Acceptable and Unacceptable Weld Profiles for Beadless Welds <\/td>\n<\/tr>\n
193<\/td>\nPM- 4.4 Chromatography Columns
PM- 4.5 Filtration Elements and Components <\/td>\n<\/tr>\n
194<\/td>\nPart CR Certification
CR- 1 PURPOSE AND SCOPE
CR- 2 GENERAL
CR- 2.1 ASME Procedures and Policies
CR- 2.2 ASME BPE Certificate Holders
CR- 2.3 ASME BPE Certificate Holder’s Responsibilities
Fig. CR- 2.3.1- 1 ASME Mark With BPE Designator <\/td>\n<\/tr>\n
195<\/td>\nFig. CR- 2.3.2- 1 Options for Certification of Organizations <\/td>\n<\/tr>\n
197<\/td>\nCR- 3 ACQUIRING AN ASME BPE CERTIFICATE
CR- 3.1 Application for Certification
CR- 3.2 Verification of Qualification <\/td>\n<\/tr>\n
198<\/td>\nCR- 3.3 Issuance of ASME BPE Certificate <\/td>\n<\/tr>\n
199<\/td>\nCR- 3.4 Denial or Loss of ASME BPE Certificate of Authorization
CR- 4 REQUIREMENTS SUBJECT TO CHANGE <\/td>\n<\/tr>\n
200<\/td>\nPart MM Metallic Materials
MM- 1 PURPOSE AND SCOPE
MM- 2 ALLOY DESIGNATIONS
MM- 2.1 General
MM- 3 USES OF SPECIFICATIONS
MM- 3.1 General
MM- 3.2 Listed Specifications
MM- 3.3 Unlisted Specifications
MM- 3.4 Unknown Materials
MM- 3.5 Reclaimed Materials
MM- 3.6 Designation of Alloy and Fluid Service <\/td>\n<\/tr>\n
201<\/td>\nMM- 4 REFERENCED SPECIFICATIONS
MM- 4.1 General
MM- 4.2 Tubing\/ Piping
Table MM- 2.1- 1 Wrought Stainless Steels: Nominal Compositions ( wt. %) <\/td>\n<\/tr>\n
202<\/td>\nMM- 4.3 Castings
Table MM- 2.1- 2 Wrought Nickel Alloys: Nominal Compositions ( wt. %) <\/td>\n<\/tr>\n
203<\/td>\nMM- 4.4 Forgings
MM- 4.5 Plate, Sheet, and Strip
Table MM- 2.1- 3 Stainless Steel and Nickel Alloy Cast Designations <\/td>\n<\/tr>\n
204<\/td>\nMM- 4.6 Hollow Products, Rod, and Bar Stock
MM- 5 FABRICATION
MM- 5.1 General <\/td>\n<\/tr>\n
205<\/td>\nTable MM- 5.1.2- 1 Filler Metals <\/td>\n<\/tr>\n
206<\/td>\nTable MM- 5.1.2- 1 Filler Metals ( Cont’d) <\/td>\n<\/tr>\n
207<\/td>\nTable MM- 5.1.2- 2 Consumable Inserts for Superaustenitic and Duplex Stainless Steels
Table MM- 5.1.4- 1 Predicted Ferrite Number ( FN) Ranges for Various 316 Product Forms and Welds <\/td>\n<\/tr>\n
208<\/td>\nMM- 5.2 Filler Metals and Consumable Inserts
MM- 5.3 Field Bending of Tubing
MM- 5.4 Heat Treatment
MM- 6 MECHANICAL PROPERTIES
MM- 6.1 General
MM- 6.2 Tubing\/ Piping
MM- 6.3 Fittings and Welded Components <\/td>\n<\/tr>\n
209<\/td>\nMM- 6.4 Toughness
MM- 6.5 Testing
MM- 7 CORROSION RESISTANCE REQUIREMENTS
MM- 7.1 General
MM- 7.2 Corrosion Testing
MM- 8 UNLISTED ALLOYS
MM- 8.1 General <\/td>\n<\/tr>\n
210<\/td>\nPart PI Process Instrumentation
PI- 1 PURPOSE AND SCOPE
PI- 2 PROCESS INSTRUMENTATION GENERAL REQUIREMENTS
PI- 2.1 General Considerations
PI- 2.2 Instrumentation Categories <\/td>\n<\/tr>\n
211<\/td>\nPI- 3 INSTRUMENT RECEIVING, HANDLING, AND STORAGE
PI- 3.1 Introduction
PI- 3.2 Instrument Receiving
PI- 3.3 Instrument Handling: Protection of Process Connections and Surface Finish
PI- 3.4 Instrument Storage
PI- 4 FLOWMETERS
PI- 4.1 Coriolis Flowmeter
Fig. PI- 2.2.1- 1 In- Line and At- Line Instrument Installation Examples <\/td>\n<\/tr>\n
212<\/td>\nFig. PI- 2.2.2- 1 Accepted Insertion Device Installation Examples <\/td>\n<\/tr>\n
213<\/td>\nFig. PI- 4.1.3.2- 1 Manifold or Flow Splitter for Dual Tube Construction Flowmeters and Potential for Product Holdup <\/td>\n<\/tr>\n
214<\/td>\nFig. PI- 4.1.3.3- 1 Concentrically Reducing Process Connection
Fig. PI- 4.1.4.3- 1 Vertical Installation Fig. PI- 4.1.4.4- 1 Minimum Angle of Inclination, <\/td>\n<\/tr>\n
215<\/td>\nPI- 5 LEVEL INSTRUMENTS
PI- 6 PRESSURE INSTRUMENTS
PI- 7 TEMPERATURE INSTRUMENTS
PI- 8 ANALYTICAL INSTRUMENTS
PI- 8.1 Conductivity <\/td>\n<\/tr>\n
216<\/td>\nFig. PI- 8.1.2- 1 Conductivity Type Examples <\/td>\n<\/tr>\n
217<\/td>\nFig. PI- 8.1.3- 1 Accepted Installations for Conductivity Sensors <\/td>\n<\/tr>\n
218<\/td>\nPI- 8.2 pH \u2014 Glass Measuring Electrode
Fig. PI- 8.1.3.6- 1 Installation Clearance Requirements <\/td>\n<\/tr>\n
219<\/td>\nFig. PI- 8.2.2- 1 pH Sensor Components <\/td>\n<\/tr>\n
220<\/td>\nFig. PI- 8.2.3- 1 Accepted pH Sensor Installations <\/td>\n<\/tr>\n
221<\/td>\nFig. PI- 8.2.3.4- 1 Accepted Mounting Orientations <\/td>\n<\/tr>\n
222<\/td>\nPI- 9 OPTICAL
PI- 9.1 Optical Devices
Fig. PI- 8.2.3.5- 1 Insertion Length or Depth <\/td>\n<\/tr>\n
224<\/td>\nFig. PI- 9.1.3.3- 1 Vessel Light Glass Design and Mounting <\/td>\n<\/tr>\n
225<\/td>\nFig. PI- 9.1.3.5- 1 In- Line Insertion Length
Fig. PI- 9.1.3.5- 2 Insertion Probe Length <\/td>\n<\/tr>\n
227<\/td>\nMANDATORY APPENDIX
MANDATORY APPENDIX I SUBMITTAL OF TECHNICAL INQUIRIES TO THE BIOPROCESSING EQUIPMENT ( BPE) COMMITTEE
I- 1 INTRODUCTION
I- 2 INQUIRY FORMAT
I- 3 REVISIONS OR ADDITIONS <\/td>\n<\/tr>\n
228<\/td>\nI- 4 CODE CASES
I- 5 INTERPRETATIONS
I- 6 SUBMITTALS <\/td>\n<\/tr>\n
229<\/td>\nNONMANDATORY APPENDICES
\n
NONMANDATORY APPENDIX A COMMENTARY: SLAG
A- 1 GENERAL <\/td>\n<\/tr>\n
230<\/td>\nNONMANDATORY APPENDIX B MATERIAL EXAMINATION LOG AND WELD LOG <\/td>\n<\/tr>\n
235<\/td>\nNONMANDATORY APPENDIX C SLOPE MEASUREMENT
C- 1 GENERAL <\/td>\n<\/tr>\n
236<\/td>\nNONMANDATORY APPENDIX D ROUGE AND STAINLESS STEEL
D- 1 GENERAL
D- 2 CONSIDERATIONS FOR REDUCING ROUGE FORMATION
D- 2.1 System Fabrication
D- 2.2 System Operation
D- 3 EVALUATION METHODS TO MEASURE ROUGE
D- 3.1 Process Fluid Analyses
D- 3.2 Solid Surface Analyses
D- 4 METHODS TO REMEDIATE THE PRESENCE OF ROUGE IN A SYSTEM
D- 4.1 Class I Rouge Remediation <\/td>\n<\/tr>\n
237<\/td>\nTable D- 2- 1 Considerations That Affect the Amount of Rouge Formation During the Fabrication of a System <\/td>\n<\/tr>\n
238<\/td>\nTable D- 2- 2 Considerations That Affect the Amount of Rouge Formation During the Operation of a System <\/td>\n<\/tr>\n
239<\/td>\nTable D- 2- 2 Considerations That Affect the Amount of Rouge Formation During the Operation of a System ( Cont’d)
D- 4.2 Class II Rouge Remediation <\/td>\n<\/tr>\n
240<\/td>\nTable D- 3.1- 1 Process Fluid Analyses for the Identification of Mobile Constituents of Rouge
D- 4.3 Class III Rouge Remediation
D- 4.4 Remediation Variables <\/td>\n<\/tr>\n
241<\/td>\nTable D- 3.2- 1 Solid Surface Analyses for the Identification of Surface Layers Composition <\/td>\n<\/tr>\n
242<\/td>\nTable D- 4.1- 1 Rouge Remediation Processes Summary <\/td>\n<\/tr>\n
243<\/td>\nTable D- 4.1- 1 Rouge Remediation Processes Summary ( Cont’d) <\/td>\n<\/tr>\n
244<\/td>\nNONMANDATORY APPENDIX E PASSIVATION PROCEDURE QUALIFICATION
E- 1 GENERAL
E- 2 PURPOSE OF PASSIVATION TREATMENTS
E- 2.1 Why Passivation Is Necessary
E- 2.2 When Passivation Is Necessary <\/td>\n<\/tr>\n
245<\/td>\nTable E- 3.2- 1 Minimum Surface Requirements for Process Qualification Samples
E- 3 PASSIVATION PROCEDURE ( SEE SF- 2.6)
E- 3.1 Procedure Description
E- 3.2 Procedure Qualification
E- 3.3 Procedure Documentation Requirements
E- 4 PASSIVATION QUALITY CONTROL
E- 4.1 Quality Control Surveillance <\/td>\n<\/tr>\n
246<\/td>\nTable E- 3.2- 2 Passivation Processes <\/td>\n<\/tr>\n
247<\/td>\nTable E- 3.2- 2 Passivation Processes ( Cont’d) <\/td>\n<\/tr>\n
248<\/td>\nTable E- 3.2- 2 Passivation Processes ( Cont’d)
E- 4.2 Certificate of Passivation Compliance
E- 5 EVALUATION OF CLEANED AND PASSIVATED SURFACES
E- 5.1 Acceptance Criteria for Cleaned and\/ or Passivated Product Contact Surfaces ( See Table SF- 2.6- 1) <\/td>\n<\/tr>\n
250<\/td>\nTable E- 5- 1 Test Matrix for Evaluation of Cleaned and\/ or Passivated Surfaces <\/td>\n<\/tr>\n
251<\/td>\nTable E- 5- 1 Test Matrix for Evaluation of Cleaned and\/ or Passivated Surfaces ( Cont’d) <\/td>\n<\/tr>\n
252<\/td>\nTable E- 5- 1 Test Matrix for Evaluation of Cleaned and\/ or Passivated Surfaces ( Cont’d) <\/td>\n<\/tr>\n
253<\/td>\nTable E- 5- 1 Test Matrix for Evaluation of Cleaned and\/ or Passivated Surfaces ( Cont’d) <\/td>\n<\/tr>\n
254<\/td>\nNONMANDATORY APPENDIX F CORROSION TESTING
F- 1 GENERAL
F- 2 CORROSION TESTS
F- 3 PITTING RESISISTANCE EQUIVALENT ( PRE) NUMBER <\/td>\n<\/tr>\n
255<\/td>\nTable F- 1- 1 ASTM Corrosion Tests <\/td>\n<\/tr>\n
256<\/td>\nTable F- 1- 1 ASTM Corrosion Tests ( Cont’d)
Table F- 3- 1 PRE Numbers for Some Alloys <\/td>\n<\/tr>\n
257<\/td>\nNONMANDATORY APPENDIX G FERRITE
G- 1 GENERAL
G- 2 INFLUENCE OF FERRITE IN BIOPHARMACEUTICAL SERVICE
G- 3 CONTROL OF FERRITE CONTENT IN WELDS OF 316 STAINLESS STEELS <\/td>\n<\/tr>\n
258<\/td>\nNONMANDATORY APPENDIX H ELECTROPOLISHING PROCEDURE QUALIFICATION
H- 1 SCOPE
H- 2 PURPOSE
H- 3 ELECTROPOLISH PROCEDURE QUALIFICATION
H- 3.1 Method Procedure
H- 3.2 Essential Variables
H- 3.3 Vendor Documentation
H- 3.4 Certificate of Compliance <\/td>\n<\/tr>\n
259<\/td>\nTable H- 3.3- 1 Minimum Surface Requirements for Process Qualification Samples <\/td>\n<\/tr>\n
260<\/td>\nNONMANDATORY APPENDIX I VENDOR DOCUMENTATION REQUIREMENTS FOR NEW INSTRUMENTS
I- 1 OVERVIEW
I- 1.1 Section 1: VDR Definitions
I- 1.2 Section 2: Instrument Types and Required Documents
I- 2 INSTRUCTIONS FOR USE <\/td>\n<\/tr>\n
261<\/td>\nTable I- 1.1 Vendor Documentation Requirements for New Instruments: Section 1, VDR Definitions <\/td>\n<\/tr>\n
262<\/td>\nTable I- 1.1 Vendor Documentation Requirements for New Instruments: Section 1, VDR Definitions ( Cont’d) <\/td>\n<\/tr>\n
263<\/td>\nTable I- 1.2 Vendor Documentation Requirements for New Instruments: Section 2, Instrument Types and Required Documents <\/td>\n<\/tr>\n
264<\/td>\nNONMANDATORY APPENDIX J STANDARD PROCESS TEST CONDITIONS ( SPTC) FOR SEAL PERFORMANCE EVALUATION
J- 1 HYGIENIC UNION SEAL PERFORMANCE EVALUATION
J- 1.1 Material Evaluation
J- 1.2 Simulated Steam- in- Place ( SIP) Testing <\/td>\n<\/tr>\n
265<\/td>\nJ- 2 MECHANICAL SEAL PERFORMANCE EVALUATION
J- 2.1 Mechanical Seal Performance Evaluation
J- 2.2 Exceptions to Normal Seal Performance
J- 2.3 Mechanical Seal Integrity Tests <\/td>\n<\/tr>\n
268<\/td>\nJ- 2.4 Mechanical Seal Testing Notes <\/td>\n<\/tr>\n
269<\/td>\nNONMANDATORY APPENDIX K STANDARD TEST METHODS FOR POLYMERS
K- 1 STANDARD TEST METHODS FOR THERMOPLASTIC POLYMERS
K- 2 STANDARD TEST METHODS FOR THERMOSET POLYMERS
K- 3 THERMOSET POLYMER TEST PROPERTIES
K- 4 INTERPRETATION OF THERMOSET MATERIAL PROPERTY CHANGES
K- 5 TESTING PROTOCOLS FOR THERMOSET POLYMERS
K- 5.1 Samples
K- 5.2 Immersion Fluids
K- 5.3 Qualification Testing
K- 5.4 Elastomer Testing: Property Retention <\/td>\n<\/tr>\n
270<\/td>\nTable K- 3- 1 Thermoset Polymer Test Properties <\/td>\n<\/tr>\n
271<\/td>\nTable K- 4- 1 Interpretation of Thermoset Material Property Changes <\/td>\n<\/tr>\n
272<\/td>\nNONMANDATORY APPENDIX L SPRAY DEVICE COVERAGE TESTING
L- 1 SCOPE
L- 2 PURPOSE
L- 3 MATERIALS
L- 4 PROCEDURE
L- 4.1 Equipment Preparation
L- 4.2 Application of Fluorescent Solution
L- 4.3 Execute Rinse <\/td>\n<\/tr>\n
273<\/td>\nL- 4.4 Inspection
L- 5 ACCEPTANCE CRITERIA
L- 6 RECOMMENDED DOCUMENTATION <\/td>\n<\/tr>\n
274<\/td>\nNONMANDATORY APPENDIX M COMMENTARY: 316L WELD HEAT- AFFECTED ZONE DISCOLORATION ACCEPTANCE CRITERIA
M- 1 GENERAL <\/td>\n<\/tr>\n
275<\/td>\nNONMANDATORY APPENDIX N GUIDANCE WHEN CHOOSING POLYMERIC AND NONMETALLIC MATERIALS <\/td>\n<\/tr>\n
276<\/td>\nNONMANDATORY APPENDIX O REFERENCES: GENERAL BACKGROUND FOR EXTRACTABLES AND LEACHABLES <\/td>\n<\/tr>\n
277<\/td>\nNONMANDATORY APPENDIX P TEMPERATURE SENSORS AND ASSOCIATED COMPONENTS
P- 1 GENERAL
P- 2 COMPONENTS
P- 2.1 Sensors
P- 2.2 Thermowells
P- 2.3 External Support Components
P- 3 INSTALLATION
P- 3.1 Drainability
P- 3.2 Cleanability
P- 3.3 Mounting Location
P- 3.4 Orientation <\/td>\n<\/tr>\n
278<\/td>\nFig. P- 3- 1 Typical Installation Styles
P- 3.5 Insertion Length\/ Depth <\/td>\n<\/tr>\n
279<\/td>\nFig. P- 3.4- 1 Accepted Elbow Orientation and Flow Direction
Fig. P- 3.4- 2 Accepted Nonintrusive Orientation and Flow Direction
P- 3.6 Special Considerations <\/td>\n<\/tr>\n
280<\/td>\nFig. P- 3.5- 1 Sensor Insertion Length, Tee Installations <\/td>\n<\/tr>\n
281<\/td>\nFig. P- 3.5- 2 Sensor Insertion Length, Elbow Installations
P- 4 PERFORMANCE
P- 4.1 Accuracy <\/td>\n<\/tr>\n
282<\/td>\nP- 4.2 Response Time
P- 4.3 Process Influences
P- 4.4 Ambient Influences
P- 5 SELECTION
P- 5.1 Sensor Selection
P- 5.2 Thermowell Selection
P- 5.3 Transmitter Selection <\/td>\n<\/tr>\n
283<\/td>\nP- 6 MAINTENANCE
P- 6.1 Sensor Calibration Verification
P- 6.2 Sensor Inspection <\/td>\n<\/tr>\n
284<\/td>\nNONMANDATORY APPENDIX Q INSTRUMENT RECEIVING, HANDLING, AND STORAGE
Q- 1 INTRODUCTION
Q- 2 INSTRUMENT RECEIVING
Q- 2.1 Warnings and Documentation
Q- 2.2 Incoming Inspection
Q- 3 INSTRUMENT HANDLING
Q- 3.1 Instrument Assembly Segregation
Q- 3.2 Component Labels
Q- 4 STORAGE <\/td>\n<\/tr>\n
285<\/td>\nNONMANDATORY APPENDIX R APPLICATION DATA SHEET <\/td>\n<\/tr>\n
287<\/td>\nForm R- 1 Application Data Sheet ( Cont’d) <\/td>\n<\/tr>\n
288<\/td>\nINDEX <\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

ASME BPE Bioprocessing Equipment<\/b><\/p>\n\n\n\n\n
Published By<\/td>\nPublication Date<\/td>\nNumber of Pages<\/td>\n<\/tr>\n
ASME<\/b><\/a><\/td>\n2012<\/td>\n300<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"featured_media":79165,"template":"","meta":{"rank_math_lock_modified_date":false,"ep_exclude_from_search":false},"product_cat":[2643],"product_tag":[],"class_list":{"0":"post-79164","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asme","8":"first","9":"instock","10":"sold-individually","11":"shipping-taxable","12":"purchasable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product\/79164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media\/79165"}],"wp:attachment":[{"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/media?parent=79164"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_cat?post=79164"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/pdfstandards.shop\/wp-json\/wp\/v2\/product_tag?post=79164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}